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FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs., 3 Treatments
Purchase options and add-ons
Brand | Frontline |
Item Form | Stick |
Scent | Unscented |
Age Range (Description) | All Life Stages |
Item Weight | 1.6 Ounces |
Active Ingredients | fipronil and (S)-methoprene |
Item Volume | 339 Milliliters |
Target Species | Dog |
Allergen Information | Abalone Free |
Dog Breed Size | Large |
About this item
- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease.
- Break the flea life cycle with FRONTLINE Plus. Specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control.
- Trusted by pet owners for over 20 years**, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days.
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products.
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations.
- Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus.
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This Item FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs., 3 Treatments | Recommendations | dummy | dummy | dummy | dummy | |
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Price | -20% $39.98$39.98 List: $49.99 | -13% $54.99$54.99 List: $62.99 | $94.99$94.99 | $14.99$14.99 | -10% $17.99$17.99 List: $19.99 | -18% $40.99$40.99 List: $49.99 |
Delivery | Get it as soon as Monday, Apr 1 | Get it as soon as Monday, Apr 1 | Get it as soon as Monday, Apr 1 | — | Get it as soon as Monday, Apr 1 | Get it as soon as Monday, Apr 1 |
Customer Ratings | ||||||
Easy to use | 3.9 | 4.4 | 4.4 | 4.0 | 3.3 | 4.2 |
Value for money | 3.0 | 3.8 | 3.8 | 3.1 | 1.7 | 3.4 |
Flavor | — | 2.6 | 2.6 | 3.3 | 2.1 | 3.0 |
Comfort | 3.3 | 4.6 | 4.6 | — | 2.4 | — |
Scent | 3.5 | 4.4 | 4.4 | — | — | — |
Sold By | Amazon.com | Amazon.com | Amazon.com | kingmo Pet | PETIQ | Amazon.com |
target audience | Dogs | Adult | Adult | Dog | Dog, Dog, Dog, Dog, Dog | Dogs |
age range | All Life Stages | All Life Stages | All Life Stages | All Life Stages | All Life Stages | All Life Stages |
scent | Unscented | No Scent | No Scent | — | — | Unscented |
form | Stick | Stick | Stick | Drops | Drops | Stick |
volume | 339 milliliters | 8.04 milliliters | 16.08 milliliters | — | — | 302.4 milliliters |
active ingredients | fipronil and (S)-methoprene | Fipronil, (S)-methoprene, Pyriproxyfen | Fipronil, (S)-methoprene, Pyriproxyfen | Fipronil 9.8%, (S)-methoprene 8.8%, OTHER INGREDIENTS 81.4%, TOTAL 100.0% | Fipronil, Cyphenothrin, (S)-methoprene | fipronil and (S)-methoprene |
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From the brand
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THE #1 NAME IN FLEA & TICK PROTECTION*
FRONTLINE Brand Products are effective topical solutions designed to help protect dogs and cats from fleas and ticks. FRONTLINE Plus and FRONTLINE Gold have formulas for dogs or cats. FRONTLINE Shield, with added mosquito repellency, is for dogs only.
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What is FRONTLINE?
FRONTLINE Brand Products are effective, easy-to-apply topical flea & tick preventives. FRONTLINE Plus and FRONTLINE Gold have formulas for dogs or cats. FRONTLINE Shield is for dogs only. All FRONTLINE Brand Products feature waterproof formulas that last a full 30 days.
Why should I protect my dog or cat from fleas & ticks?
Fleas & ticks are a year-round threat. FRONTLINE Brand Products help protect dogs or cats from these pests and monthly use can help prevent infestations.
From the manufacturer
How to Apply FRONTLINE Plus for Dogs
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Read full instructions on packaging before use. Shown here: Size Large 45-88 lbs. |
Use scissors to separate one blister. Hold applicator upright with foil side toward you and snap applicator tip off. |
Part dog’s hair between shoulder blades until skin is visible. |
Place applicator tip directly against exposed skin and apply entire contents directly to the skin. Do not apply on top of hair. |
FRONTLINE Plus for Small Dogs | FRONTLINE Plus for Medium Dogs | FRONTLINE Plus for Large Dogs | FRONTLINE Plus for X-Large Dogs | FRONTLINE Plus for Cats | |
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Customer Reviews |
4.4 out of 5 stars
43,559
|
4.4 out of 5 stars
20,962
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4.5 out of 5 stars
13,632
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4.6 out of 5 stars
3,617
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4.4 out of 5 stars
43,348
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Recommended pet size | 5 to 22 pounds | 23 to 44 pounds | 45 to 88 pounds | 89 to 132 pounds | Cats and kittens over 1.5 pounds |
Kills adult fleas, flea eggs, and flea larvae | ✓ | ✓ | ✓ | ✓ | ✓ |
Kills ticks and chewing lice | ✓ | ✓ | ✓ | ✓ | ✓ |
Minimum age of pet for use | Dogs and puppies 8 weeks and older | Dogs and puppies 8 weeks and older | Dogs and puppies 8 weeks and older | Dogs and puppies 8 weeks and older | Cats and kittens 8 weeks and older |
Available sizes | 3, 6 and 8-Dose | 3, 6 and 8-Dose | 3, 6 and 8-Dose | 3, 6 and 8-Dose | 3, 6 and 8-Dose |
Do not use on cats | Do not use on cats | Do not use on cats | Do not use on cats | For use on cats only |
Product guides and documents
Product details
- Is Discontinued By Manufacturer : No
- Product Dimensions : 5.75 x 0.75 x 4.5 inches; 1.6 ounces
- Manufacturer recommended age : 1 month and up
- Item model number : 72219
- Department : Insect Control
- Date First Available : September 2, 2004
- Manufacturer : Boehringer Ingelheim Animal Health
- ASIN : B0002J1FOE
- Country of Origin : Germany
- Best Sellers Rank: #328 in Pet Supplies (See Top 100 in Pet Supplies)
- #5 in Dog Flea Drops
- Customer Reviews:
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Videos
Videos for this product
1:16
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Honest Review of Frontline Plus for Dogs
Reviews with Carissa
Videos for this product
0:30
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How To Apply Frontline Plus For Dogs
Boehringer Ingelheim Animal Health
Videos for this product
1:27
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Chewy and I review this Flea Medication
Just Jules Reviews
Product Description
Keep your dog protected with the #1 name in flea & tick protection*, FRONTLINE®. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years**— FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: *Data on file at Boehringer Ingelheim. **Data showing 20 years of trust in killing fleas and ticks is on file at Boehringer Ingelheim.
Important information
Safety Information
KEEP OUT OF REACH OF CHILDREN. WARNING: PRECAUTIONARY STATEMENTS - HAZARDS TO HUMANS: WARNING. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid Contact with skin. Harmful if swallowed. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash clothing that may have come in contact with the product before reuse. HAZARDS TO DOMESTIC ANIMALS: For external use on dogs ONLY. Do not use on animals other than dogs. Do not use on dogs under 9 weeks of age or weighing less than 5 lbs. Individual sensitivities may occur after using ANY pesticide product. Dogs may experience some temporary irritation at the site of product application. If signs of sensitivity occur, bathe your dog with mild soap or shampoo and rinse with large amounts of water. If signs of sensitivity occur and persist, contact a veterinarian immediately. If your dog has an unusual reaction to the initial application, consult a veterinarian before repeating application. Certain medications can interact with pesticides. Consult a veterinarian before using on medicated, debilitated, aged, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products. Consult a veterinarian for guidance on use against Sarcoptes mites. This product is not a substitute for a prescribed heartworm preventative.nCall 1-888-637-4251, for assistance. PHYSICAL OR CHEMICAL HAZARDS: Do not allow this product to come in contact with an oxidizing agent, as a hazardous chemical reaction may occur Harmful if swallowed. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid contact with skin. Wear (specify appropriate protective eyewear such as goggles, face shield, or safety glasses). Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash contaminated clothing before reuse.
Ingredients
Fipronil (9.8%)|(S)-Methoprene (8.8%)
Directions
Directions for Use Step 1. To REMOVE Applicator: 1. Use scissors to separate one blister; 2. Use scissors to cut along dotted line; 3. Peel down foil to remove the applicator. Step 2. OPEN Applicator. Hold upright with foil side toward you and snap applicator tip. Step 3. APPLY FRONTLINE Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the dog’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Do not allow your dog to ingest the product. Do not apply to dogs weighing less than 45 lbs. or younger than 8 weeks of age. Do not use more than one application per dog per month. Frequency Use monthly to control fleas and ticks. Do not reapply FRONTLINE Plus for 30 days.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.
Customer reviews
Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them.
To calculate the overall star rating and percentage breakdown by star, we don’t use a simple average. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. It also analyzed reviews to verify trustworthiness.
Learn more how customers reviews work on AmazonCustomers say
Customers like the quality and ease of use of the pet supplies. For example, they mention it's a good solid product, it lasts 30+ days and it goes on easy. That said, opinions are mixed on performance, side effects, effectiveness, protection, and value.
AI-generated from the text of customer reviews
Customers like the quality of the pet supplies. For example, they mention it's a good solid product that lasts 30+ days. Some say that the product appears intact, but the packaging had clearly already been opened. That said, most are happy with the product and find it easy to apply.
"...A good product for the price and it definitely last 30+ days." Read more
"...exceed 750PPM companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price...." Read more
"Good quality and great buy. Works as advertised." Read more
"...The tick was full, like a berry, and utterly disgusting, but the product worked. The tick was dead, as promised...." Read more
Customers find the application of the pet supplies straightforward and easy. They also say it works well and is easy to dispense.
"The product is easy to use with easy to follow instructions! Works great for my girl and keeps her free of fleas and ticks!..." Read more
"...My dog has not bit or scratched himself and its very easy to apply on the back of his neck!" Read more
"Easy to apply" Read more
"Easy to use, always opt for these for our dogs" Read more
Customers like the speed of the pet supplies. For example, they mention it works fast to get rid of flees, and is efficient. Some say the product is waterproof and goes on quick. The results were noticeable within 2 days. Overall, most are satisfied with the speed and effectiveness of the product.
"I like how fast acting this treatment is !" Read more
"Probably the best price you’ll find for Frontline anywhere. Works pretty fast and my dogs aren’t scratching anymore." Read more
"...It worked incredibly fast and effectively, providing relief for my furry friend almost immediately...." Read more
"Loves this product for dogs!! It works fast and is great if you are on a budget." Read more
Customers are mixed about the performance of the pet supplies. Some mention that it works great, is effective, and has always worked within a few days. However, others say that it doesn't seem to work that well, maybe for a week, and stops working about 2 weeks before the next dose.
"...and because the product didn’t kill a tick before it bit my dog, I give it an average of 3 stars...." Read more
"The product is easy to use with easy to follow instructions! Works great for my girl and keeps her free of fleas and ticks!..." Read more
"I used it on my dog it doesn't seem to work that well maybe for a week she is a indoor dog and feel like I wasted my money I know I have used it..." Read more
"...I have used this for the last 3 months and it seems to work well...." Read more
Customers are mixed about the effectiveness of the pet supplies. Some mention that it is very effective keeping the fleas and ticks off, and is the number one flea and tick prevention. However, others say that it didn't kill off all flea eggs within 48 hours, and a few days later their dogs still have flea.
"...Works great for my girl and keeps her free of fleas and ticks! Leaves her ready for adventure!" Read more
"...around 80 percent of the contents of Frontline Plus are not chemicals that fight pests, they are ethanol, glycol ether, and otherwise “inactive”..." Read more
"No fleas!!" Read more
"...I got this and put it on them. It did not kill off all fleas and eggs and such within 48 hours...." Read more
Customers are mixed about the value of the pet supplies. Some mention it's very good for the price, while others say it'll be a waste of money.
"...A good product for the price and it definitely last 30+ days." Read more
"...I learned.Waste of time and money." Read more
"Good quality and great buy. Works as advertised." Read more
"Price and effectiveness." Read more
Customers are mixed about the side effects of the pet supplies. Some mention that it caused no irritation, does not hurt their skin or fur, and does not cause their dog to itch. However, others say that it made their poor pup itch even more, develop numerous itchy bumps on their skin, and cause hair loss.
"...Repurchased the following month & now she is having allergic reaction. Itching & scratching. She has even lost a layer of hair...." Read more
"...Both of the chemicals, S-Methoprene and Fipronil are harmless to mammals...." Read more
"...reaction to the flea bites that she has itched herself raw and has dermatitis bumps...." Read more
"...after applying the product both are free of live fleas and look much more comfortable...." Read more
Customers are mixed about the protection of the pet supplies. Some mention it's great protection, safe, and effective, while others say it'll harm your pet.
"...Permethrin is a lethal neurotoxin that flows through the dogs circulatory system and flushes into every major organ - including the brain where it..." Read more
"...They are happy, I am happy. And it didn't break the bank." Read more
"...This stuff has done NOTHING to prevent or kill any fleas. I end up having to use capstar to kill the fleas- and that only lasts 24hrs...." Read more
"Have used this product for years , provides good protection for my dog from" Read more
Reviews with images
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Reviewed in the United States on March 16, 2024
After applying the capsule to our dog’s back, we took her on the trails the following week and after checking her right after, we didn’t find any ticks. However, two days later she did manage to scratch a tick off of her and fling it onto the coffee table! The tick was full, like a berry, and utterly disgusting, but the product worked. The tick was dead, as promised.
It should be made known that although the tick was dead, and so it was unable (supposedly) to lay eggs on our dog (typically a tick will lay 50 eggs a day on your dog, I read, while Frontline claims to kill ticks within hours before this can happen), ticks can obviously still bite your dog with this product on them, which can still effectively expose your dog to Lyme disease. This bothers me, since the idea behind applying it in the first place was that we don’t want ticks biting her at all so she can avoid Lymes altogether. The product lost some points with me here.
The company, Merial, which manufactures Frontline, is a global company responsible for producing vaccines and medications for farm animals as well as pets. They seem to have a reputable track record, with 5 manufacturing sites in the United States as well as other countries. According to my research, and what is posted on the Merial website, Frontline Plus uses two major chemicals to achieve results of killing fleas and ticks. Both of the chemicals, S-Methoprene and Fipronil are harmless to mammals. According to one report I read online, however, about 5% of the fipronil does get absorbed into the dog’s bloodstream, which can metabolate into a different compound which can be up to 20% more harmful to your dog than it is to the insects. The website where I found that information, Dogs Naturally Magazine, seems a bit biased, though, in its interests.
Further research showed that around 80 percent of the contents of Frontline Plus are not chemicals that fight pests, they are ethanol, glycol ether, and otherwise “inactive” ingredients. Since these “other” ingredients are inert, Merial doesn’t have to disclose much about them. I didn’t notice any weird side effects with my dog after using Frontline, but part of me still wonders if it’s the safest thing for her, since the company didn’t list the other ingredients in the product. It’s a bit off-putting.
After doing some research, it does appear vets have conflicting ideas about Frontline use. Some believe it is linked to major illness that can potentially be linked to a dog’s death, while others claim there is nothing to be concerned about. Many respond to the rumors that Frontline is not healthy for dogs by acknowledging that many people apply the product incorrectly to their dog, resulting in pets having a reaction. Also, you’re not supposed to put the product onto raw skin areas or open wounds on your pet, or feed it to your pet, as the box also warns.
The consensus among most veterinarians, and myself, is that while there are more natural ways of protecting your dog against ticks (some people suggest neem oil as a good alternative - whatever that is!), using more natural methods may result in your dog getting more ticks, which may then lead to higher risks of contracting tick-borne illness. In a place where the tick problem is so rampant, like where we live, I’d rather not take my chances. Not using a chemical prevention method is a tradeoff many pet owners feel is not worth the risk.
Overall, the product did what it said it was going to do, and for that it gets 5 stars. But because I don’t have a clear idea of what “other ingredients” are (the company does not disclose them on the packaging), and because the product didn’t kill a tick before it bit my dog, I give it an average of 3 stars. My expectations were higher than what the product delivered. Although, this was my pet’s first time using Frontline, so I’m wondering if more consistent treatment will lead to better results.