Life Extension Optimized Folate (l-methylfolate), 1000 Mcg, Vegetarian Tablets, 100-Count
Purchase options and add-ons
Brand | Life Extension |
Item Form | Tablet |
Primary Supplement Type | Vitamin B9 |
Diet Type | Vegetarian |
Flavor | Unflavored |
About this item
- Folate benefits cardiovascular health and nervous system function
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PRODUCT CERTIFICATION (1)
Compact by Design (Amazon-developed Certification)products have reduced water and/or air in the product or packaging for more efficient transportation.
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From the manufacturer
Life Extension Optimized Folate (l-methylfolate)
Our Optimized Folate formula promotes both cardiovascular and cognitive health with 1,000 mcg of folate in the form of L-Methylfolate.
- Supports both cardiovascular & cognitive health
- Helps maintain already-healthy homocysteine levels
- Delivers 1,000 mcg of the B vitamin folate
Folate Promotes Heart and Brain Health
Folic acid is a common B-vitamin supplement. Folate helps maintain healthy homocysteine levels already within the normal range. Homocysteine levels are an important biomarker for both cardiovascular and cognitive health—so be proactive. This formula delvers 1,000 mcg of L-Methylfolate. If you’re looking for 5-MTHF folate, try our High Potency Optimized Folate formula.
Product Description
Optimized Folate (L-Methylfolate), 1000 mcg, 100 vegetarian TABLETS. Optimized Folate (L-Methylfolate)1000 mcg, 100 vegetarian TABLETS. Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function. Those who take ordinary folic acid supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called 5-methyltetrahydrofolate (5-MTHF). Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher than desired homocysteine). A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise blood serum folate levels compared with folic acid supplementation. This bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency since it requires no conversion to become metabolically active
Product details
- Is Discontinued By Manufacturer : No
- Product Dimensions : 4 x 4 x 4 inches; 1.6 ounces
- Item model number : 1312
- Date First Available : May 30, 2004
- Manufacturer : Life Extension
- ASIN : B002R3G8BS
- Best Sellers Rank: #20,322 in Health & Household (See Top 100 in Health & Household)
- Customer Reviews:
Product guides and documents
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This Item Life Extension Optimized Folate (l-methylfolate), 1000 Mcg, Vegetarian Tablets, 100-Count | Recommendations | dummy | dummy | dummy | dummy | |
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Price | -12% $15.99$15.99 Typical: $18.11 | -33% $19.95$19.95 List: $29.96 | $21.99$21.99 | $23.87$23.87 | -7% $29.99$29.99 Typical: $32.10 | -19% $12.95$12.95 List: $15.95 |
Price Per Unit | $0.16 / Count | $0.08 / Count | $0.37 / Count | $23.87 / Count | $0.10 / Count | $0.11 / Count |
Delivery | Get it Mar 27 - Apr 1 | Get it as soon as Sunday, Mar 24 | Get it as soon as Sunday, Mar 24 | Get it as soon as Sunday, Mar 24 | Get it Mar 27 - 29 | Get it as soon as Sunday, Mar 24 |
Customer Ratings | ||||||
Absorbency | 4.7 | 4.8 | 4.5 | 4.5 | 4.5 | 4.4 |
Easy to swallow | 4.7 | 5.0 | 4.6 | 4.9 | 4.9 | 4.6 |
Flavor | 4.5 | 4.4 | 4.3 | 4.3 | 4.3 | 4.5 |
Value for money | 4.5 | — | 4.6 | 4.7 | 4.7 | 3.8 |
Sold By | AchillesFBA | Bayland Health | Triquetra Health | PHARMCO | Lovinio | eSupplements |
primary supplement | Vitamin B9 | — | Vitamin B12 | — | — | Vitamin B9 |
form | Tablet | Capsule | Capsule | Tablet | Tablet | Capsule |
unit count | 100 | 240 | 60 | 1 | 300 | 120 |
flavor | Unflavored | Unflavored | Unflavored | Unflavored | Unflavored | Unflavored |
target gender | female | — | unisex | unisex | unisex | unisex |
weight | 0.1 pounds | 0 ounces | 0 pounds | 0.2 pounds | 0.11 pounds | 0.08 kilograms |
specific uses | Nerve | Energy | Brain | — | — | — |
Videos
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Video review for Life Extension optimized folate 180 tablets
PJ & KJ
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Optimized Folate - Life Extensions, Best brand for MTFR
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1:10
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Life Ext Methylfolate - Why I Started Taking & My Results
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Important information
Safety Information
Keep out of reach of children. Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged. f you have a bad reaction to product discontinue use immediately. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Ingredients
Folate (1000 mcg). Folate (as 5-Methyltetrahydrofolic acid (5-MTHF), and calculated based upon the biologically Active 6S isomer). microcrystalline cellulose, vegetarian capsule, magnesium stearate, silicon dioxide.
Directions
Take one capsule daily with meals, or as recommended by a healthcare practitioner.
Legal Disclaimer
WARNING: Consuming this product can expose you to chemicals including lead, which are known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov/food.
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
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Customer reviews
Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them.
To calculate the overall star rating and percentage breakdown by star, we don’t use a simple average. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. It also analyzed reviews to verify trustworthiness.
Learn more how customers reviews work on AmazonCustomers say
Customers like the size, value, energy, headache, and mental health of the vitamin. They mention that it's easy to take, provides more energy, and helps to stabilize their mood. Some are also satisfied with the effect on skin, ease of swallowing, and quality.
AI-generated from the text of customer reviews
Customers are satisfied with the quality of the vitamin. They mention that it is effective and noticeably helpful. They also appreciate the great price and the great dosage.
"Great product" Read more
"...This stuff is amazing. Has literally changed hundreds of people's lives in my sphere of influence...." Read more
"Works and inexpensive." Read more
"Works good for me. Prescribed by doctor, also suggested brand." Read more
Customers appreciate the value of the vitamin. They say it is effective as a super expensive alternative and is delivered in excellent condition.
"Easy to take and good value for the price." Read more
"Works and inexpensive." Read more
"...The price is right, so if you think you have an issue with folate absorption give it a try." Read more
"...The pill is tiny, easy to swallow and has no taste. It is well worth the money spent." Read more
Customers like the effect on skin of the vitamin. They say it helps minimize side-effects, and is better than just folic acid. Some say it makes a difference in their blood work and makes thier life better. They also mention that it helps out with other medicines and makes them happier. Overall, customers are happy with the product and recommend it to others.
"...with the added assistance of therapy, it has made such a tremendous difference on my life...." Read more
"...Since the benefits are so good I have found a level that seems to provide me with the benefits but not the negative side effects of the irregular..." Read more
"...these vitamins for at least 6 months now, and I have not had any side affects or reactions; I think they are working well for me!..." Read more
"...taking this supplement for several months and I believe it has helped me quite a bit with my treatment resistant depression...." Read more
Customers like the effect on their mental health, saying that it helps stabilize their mood, makes them more mentally alert, and makes them feel calmer. Some customers also mention that it makes a huge difference in their antidepressant and that it works fantastic for their mood.
"...In combination with an SNRI antidepressant, this works fantastic for my mood, which indicates that I did, in fact, lack the gene (MFHR)...." Read more
"...I felt calmer the next day, (ADHD) I didn't feel tired and no longer wanted to take a nap after work every day...." Read more
"...I can say that this product works for me to stay level, happy and reduce even the season affective disorder-like symptoms that I would often get in..." Read more
"Hoping this will help with depression and anxiety" Read more
Customers like the ease of swallowing the vitamin. They mention that it's small, easy to swallow, and doesn't have a flavor. Some say that it seems easier on their stomach.
"...Every order has arrived quickly. The tablets are easy to swallow and have almost no taste." Read more
"...This is a teeny tiny little tablet, very easy to swallow...." Read more
"...The pill is tiny, easy to swallow and has no taste. It is well worth the money spent." Read more
"...They are small so easy to swallow and don't have a flavor." Read more
Customers are satisfied with the energy provided by the l-methylfolate. They mention that it provides them with more energy and focus, and it is helping them with their chronic fatigue. Some customers also report that the product has improved their heart health.
"...acid levels retested, but these pills seem like a good dose for me- I feel more energetic and my nerve pain and anxiety seem a bit better...." Read more
"...I felt calmer the next day, (ADHD) I didn't feel tired and no longer wanted to take a nap after work every day...." Read more
"...I think so much more clearly now, and I also have more energy. The pills are very small, too, and it only takes one of them a day to do the trick...." Read more
"This is a great product for those with fatigue caused by Methylfolate deficiency, especially those with a MTHFR mutation...." Read more
Customers like the effect on headache. They say that they are feeling better, it seems to help with the pain, and is easier on their body. Some customers also say that it has helped them get some of the symptoms under control. They also mention that they have no issues with upset stomach or other side effects, and that their stomach feels flatter.
"...pills seem like a good dose for me- I feel more energetic and my nerve pain and anxiety seem a bit better...." Read more
"...Plus it’s easier on my body. Would recommend to others and continue to take it myself." Read more
"...pills and within an hour I felt my brain tingling, and my crazy symptoms went away. This stuff works...." Read more
"It helped right away my head felt better, but my bowels started gripping. I am very sensitive so Iam going to use it for a couple of days ...." Read more
Customers like the size of the vitamin. They say it's easy to take, because the capsules are very small. Some say that the tablet is a teeny tiny little one.
"...The pills are very small, too, and it only takes one of them a day to do the trick. THANK YOU." Read more
"...This is a teeny tiny little tablet, very easy to swallow...." Read more
"...The pill is tiny, easy to swallow and has no taste. It is well worth the money spent." Read more
"Dr said I should take for neuronopathy. So I do. These are small and easy to swallow." Read more
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If I asked you which of these vitamins was found naturally in food, folate or folic acid, would you know the answer? If not, you’re in good company.
Many health professionals would even argue that folate and folic acid are essentially the same nutrient. While folic acid is often considered to be a supplemental form of folate, there is an important distinction between these two different compounds.
What’s the difference between folate and folic acid?
Folate is a general term for a group of water soluble b-vitamins, and is also known as B9. Folic acid refers to the oxidized synthetic compound used in dietary supplements and food fortification, whereas folate refers to the various tetrahydrofolate derivatives naturally found in food.
The form of folate that can enter the main folate metabolic cycle is tetrahydrofolate (THF). Unlike natural folates, which are metabolized to THF in the mucosa of the small intestine, folic acid undergoes initial reduction and methylation in the liver, where conversion to the THF form requires dihydrofolate reductase. The low activity of this enzyme in the human liver, combined with a high intake of folic acid, may result in unnatural levels of unmetabolized folic acid entering the systemic circulation.
Risks associated with excessive folic acid intake.
One of the major risks associated with excessive intake of folic acid is the development of cancer. In patients with ischemic heart disease in Norway, where there is no folic acid fortification of foods, treatment with folic acid plus vitamin B12 was associated with increased cancer outcomes and all-cause mortality. In the United States, Canada, and Chile, the institution of a folic acid supplementation program was associated with an increased prevalence of colon cancer. A randomized control trial found that that daily supplementation with 1 mg of folic acid was associated with an increased risk of prostate cancer.
A high intake of folic acid might mask detection of vitamin B12 deficiency and lead to a deterioration of central nervous system function in the elderly.
L-methylfolate or 6(S)-5-methyltetrahydrofolate [6(S)-5-MTHF], is the primary biologically active diastereoisomer of folate and the primary form of folate in circulation. It is also the form which is transported across membranes into peripheral tissues, particularly across the blood brain barrier.
Folic acid, the synthetic form of folate, must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active. Genetic mutations of MTHFR result in a cell’s inability to convert folic acid to 6(S)-5-MTHF.
I got rid of Folic Acid on sale in Pharmacy, and I'm using L-Methylfolate. Be sure you buy L-Methylfolate, don't use Folic Acid, Plain Methylfolate (mixture 50% L-Methylfolate and 50% D-Methylfolate) and don't buy D-Methylfolate.
I tried it after coming across several articles about the linkage between bipolar and absence of the gene for metabolizing folic acid, which is a B vitamin related to "resilience". The enzyme produced by the gene turns folic acid into L-methylfolate. When manufactured, there apparently is an "M" version and an "L" version, of which the M is cheaper and the articles say is not effective. At my Whole Foods store, I checked the labels on all the brands of "folate" they had, and none specifically said "L-methyl", but bought two anyway, and also bought this from Amazon because it specifies "L-methyl" which the articles I read said was the effective version. In use, this was the only one of the three that worked, and did it ever work! I wish the improvement to my life upon everyone with similar feelings when depressed.. writing this review to help those of you out there still suffering.
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