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THORNE 5-MTHF 1mg - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules

4.7 4.7 out of 5 stars 2,710 ratings
Amazon's Choice highlights highly rated, well-priced products available to ship immediately.
Amazon's Choice in Vitamin B9 (Folic Acid) Supplements by THORNE

Sustainability features

This product has sustainability features recognized by trusted certifications.

Packaging efficiency

Reduced air and/or water in the product or packaging for more efficient transportation.

As certified by
Compact by Design (Amazon-developed Certification) Compact by Design (Amazon-developed Certification)

Compact by Design identifies products that, while they may not always look very different, have a more efficient design. By reducing water and/or air in the product or packaging, these become more efficient to ship. At scale, these small differences in product size and weight lead to significant carbon emission reductions.

Learn more about this certification

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Climate Pledge Friendly

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Purchase options and add-ons

Brand THORNE
Item Form Capsule
Primary Supplement Type Vitamin-b
Diet Type Gluten Free
Flavor Unflavored

About this item

  • Healthy Methylation: A breakthrough in active folate supplementation for healthy methylation*
  • Positivity: Supports a healthy outlook*
  • Nerves & Circulation: Supports healthy blood vessel and nerve function*
  • Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health*
  • Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams
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THORNE 5-MTHF 1mg - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules

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Sustainability features

Sustainability features

This product has sustainability features recognized by trusted certifications.

Packaging efficiency

Reduced air and/or water in the product or packaging for more efficient transportation.

As certified by
Compact by Design (Amazon-developed Certification) Compact by Design (Amazon-developed Certification)

Compact by Design identifies products that, while they may not always look very different, have a more efficient design. By reducing water and/or air in the product or packaging, these become more efficient to ship. At scale, these small differences in product size and weight lead to significant carbon emission reductions.

Learn more about this certification

Part of
Sustainability features
Climate Pledge Friendly

Product Description

5-mthf

5-MTHF is an active, tissue-ready form of folate. It’s an essential B vitamin that supports healthy methylation, fetal development, positivity, and cardiovascular and nerve function.*

Greater Absorption

Researched

Researched

Thorne Bestseller

Greater Absorption

Thorne's 5-MTHF includes an active ingredient that is tissue-ready and in its most bioavailable form for better absorption.*

Well-Researched Benefits

A greater blood level of 5-MTHF (active folate) is achieved after supplementation with 5-MTHF compared to folic acid supplementation.*

Well-Researched Benefits

In conjunction with vitamin B12, 5-MTHF functions as a methyl-group donor, which facilitates the conversion of the undersirable amino acid homocysteine to the more desirable methionine.* Methyl-group donation is vital to many necessary biochemical conversion processes, including the synthesis of serotonin, melatonin, and DNA.*

Trusted Manufacturer

For more than 30 years, Thorne has been trusted by health-care practitioners who prescribe our products to their patients. In addition, our products are now recommended by U.S. National Teams and multiple professional sports teams for their elite athletes. Thorne products are a testament to Thorne's mission to provide high-quality supplements that are tested for quality, safety, and efficacy.

Heart/Vessels

If supporting your heart and cardiovascular system is your objective, then diet will always play a big role. However, nutritional supplementation can partner with a healthy diet and exercise to provide additional support for blood vessel health, heart muscle function, maintenance of normal cholesterol, support for healthy blood pressure, and balanced methylation.*

Innovative solutions

When the highest standards have been met, Thorne creates higher ones.

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Sourcing Exceptional Ingredients

We develop better standards for higher quality ingredients. Thorne cares deeply about where our ingredients come from. We partner only with suppliers whose practices emphasize quality, science, and responsibility. Better ingredients means better potency, absorption, and digestibility - and ultimately better health.

Manufacturing the Right Way

We manufacture our own products to ensure full supply chain transparency. For more than 30 years, we have invested in clean manufacturing practices. We refuse to use ingredients that can inhibit absorption. We perform our final production in the United States. Our Charleston, SC facility is third-party certified.

Four Rounds of Testing

We perform four rounds of testing for each product we manufacture – far above the industry standard. Thorne has invested in two state-of-the-art in-house laboratories that enable us to conduct four rounds of testing, including raw material testing, in-process batch testing, finished product testing, and expiration date stability testing for each lot of product that we manufacture.

Thinking Sustainably

We're thinking sustainably to protect our environment. We believe the environment should never be compromised for the sake of business gain. At Thorne, we believe that doing our part to protect the environment and its most valuable resources goes hand in hand with our product quality standards.


Focus on sustainability

Compact by design from Climate pledge friendly. Certified by Amazon.

Small changes in product size & weight lead to lower carbon emissions.

We created Compact by Design to identify products that, while they may not always look very different, have a more efficient design. With the removal of excess air and water, products require less packaging and become more efficient to ship. At scale, these small differences in product size and weight lead to significant carbon emission reductions.

Here are a few of the many ways products can qualify:

Less packaging

Less air in container

More efficient shape

Waterless technology

Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Item model number ‏ : ‎ B129
  • Date First Available ‏ : ‎ December 10, 2007
  • Manufacturer ‏ : ‎ Thorne Research
  • ASIN ‏ : ‎ B00FY8IQ7C
  • Customer Reviews:
    4.7 4.7 out of 5 stars 2,710 ratings

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THORNE 5-MTHF 1mg - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules
THORNE 5-MTHF 1mg - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules
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THORNE 5-MTHF 5mg - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules
Details
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Price$23.00$32.88-39% $7.95
List:$12.99
-10% $26.99
List:$29.99
$21.99-14% $51.72
List:$60.00
Price Per Unit$0.38 / Count$0.18 / Count$0.07 / Count$0.22 / Count$0.37 / Count$0.86 / Count
Delivery
Get it as soon as Wednesday, Mar 27
Get it as soon as Wednesday, Mar 27
Get it as soon as Wednesday, Mar 27
Get it as soon as Wednesday, Mar 27
Get it as soon as Wednesday, Mar 27
Customer Ratings
Easy to swallow
4.8
4.8
5.0
5.0
4.6
4.8
Value for money
4.3
4.4
4.7
5.0
4.6
4.1
Flavor
4.3
5.0
4.8
5.0
4.3
4.3
Absorbency
4.4
4.5
4.5
4.8
Sold By
Pattern.
AMZ CENTER
Nature's Fusions Nutri
Nature's Fusions Nutri
Triquetra Health
FTG Goods
primary supplement
Vitamin-b
Vitamin B9
Tablet
Tablet
Vitamin B12
Vitamin-b
form
Capsule
Capsule
Tablet
Tablet
Capsule
Capsule
unit count
60
180
120
120
60
60
flavor
Unflavored
Unflavored
Unflavored
Unflavored
Unflavored
target gender
unisex
unisex
unisex
unisex
unisex
weight
1 milligrams
0 ounces
0 pounds
5 milligrams
specific uses
Nerve
Brain
Mouth
Methylfolate
Brain
Nerve

Important information

Safety Information

If pregnant, consult your health-care practitioner before using this product. 5-methyl-tetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate.

Indications

Folate Support

Ingredients

One Capsule Contains: Folate (1 mg as L-5-Methyltetrahydrofolate) 1.7 mg DFE Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.

Directions

Take 1 capsule one to three times daily or as recommended by a health-care practitioner.

Legal Disclaimer

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Please contact your healthcare professional immediately if you experience any unwanted side effects. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Looking for specific info?

Customer reviews

4.7 out of 5 stars
4.7 out of 5
2,710 global ratings

Customers say

Customers like the quality, value, and ease of swallowing of the vitamin. For example, they mention it's easy to absorb, helps maintain B vitamin levels, and is the best bang for the buck. Opinions are mixed on the side effects.

AI-generated from the text of customer reviews

112 customers mention107 positive5 negative

Customers are satisfied with the quality of the vitamin. They mention that it's a great product, easy to take, and a reliable brand. Some say that it is highly recommended by three doctors. Overall, customers are happy with their purchase and recommend it to others.

"...And as always I trust THORNE PRODUCTS WITH MY LIFE. They are high quality and third party tested for heavy metals...." Read more

"...It has worth every penny paying out of pocket for this supplement...." Read more

"...Always excellent quality." Read more

"...This is definitely a supplement that’s worth trying." Read more

40 customers mention36 positive4 negative

Customers are satisfied with the performance of the vitamin. They say it works well for them, and is absolutely amazing. They also say it synergistically works with antidepressants and probiotics, and has helped immensely. Customers also like the verified potency and the fact that it works best with small sensible meals.

"...What this product does is absolutely amazing! It helps your body to methylate properly so you can absorb certain nutrients probably!..." Read more

"...These work great to bypass this mutation...." Read more

"Easy small capsule to swallow. Seems to work well in conjunction with probiotic" Read more

"Works synergistically with antidepressants, 15mg was prescribed to me by my psychiatrist to be used with two other medications...." Read more

40 customers mention35 positive5 negative

Customers like the sleep quality of the vitamin. They say they feel more energetic, in a better mood, and have more focus. Some say that the medication has made a great improvement in their energy level, and they feel less tired.

"...He takes one in the morning daily and he reports it helps him feel focused, less anxious or irritable, he is in a good mood, and isn’t groggy or..." Read more

"...I did notice a slight uptick in my energy levels. When I take it with this energy supplement from Fasted Athlete I can really feel the effects...." Read more

"...My mood has seemed to improve and my energy levels are so much better: I didn’t even feel the needs to take a nap on a rainy Sunday while my..." Read more

"...I feel more energetic, in a better mood.The container is a lot smaller than I thought from the pictures." Read more

33 customers mention33 positive0 negative

Customers find the absorbency of the vitamins great. They say it's a top-notch dietary supplement that helps maintain their B vitamin levels. They also mention that the form of folate, L-5-MTHF, is much healthier than the common form, better known as folic acid. Customers also say the supplement is excellent for providing the folate that their body cannot produce.

"...It helps your body to methylate properly so you can absorb certain nutrients probably! And as always I trust THORNE PRODUCTS WITH MY LIFE...." Read more

"...I don’t need to take with food. Perfect for people who need methylated folate and great price!" Read more

"...It also seems to help his overall health and he’s finally grown taller and gained weight thanks to being able to better absorb nutrients from his..." Read more

"...Thorne is a solid company with great ingredients.I did notice a slight uptick in my energy levels...." Read more

30 customers mention24 positive6 negative

Customers like the value of the vitamin. They mention it's a great product at a good price, and it provides the best bang for the buck.

"...Perfect for people who need methylated folate and great price!" Read more

"...In all honesty, the price isn't too bad either for the quality of product you receive...." Read more

"The price is reasonable" Read more

"I like this product, not the upwards price drift! It’s gone from 15.00, now 19.00!" Read more

25 customers mention25 positive0 negative

Customers find the vitamin easy to swallow. They mention it's a small, easy to digest pill that doesn't upset their stomach. Some say that the dose is small enough that they take it every other day. Overall, most are happy with the product's ease of use.

"I found out I have MTHFR gene mutation. This is a small enough dose that I take it every other day. I don’t want to take too much...." Read more

"...Very small capsule is easy to swallow" Read more

"Easy to take product, great brand" Read more

"Easy small capsule to swallow. Seems to work well in conjunction with probiotic" Read more

34 customers mention21 positive13 negative

Customers are mixed about the side effects of the vitamin. Some mention that it helps with minor anxiety issues, reduces or takes away the headache, and curbs persistent nightmares. However, others say that it made them sick at first, tired, and produced awful side effects on their body.

"...the morning daily and he reports it helps him feel focused, less anxious or irritable, he is in a good mood, and isn’t groggy or feel fuzzy like..." Read more

"...I don’t want to take too much. It made me sick at first and really tired, but that’s very normal. I feel fine taking it now with no problem...." Read more

"...I take two per day, I sleep better, feel less stressed, and my migraine attacks have been reduced about 90% in both, frequency and strength...." Read more

"...This pill changed all of that! I am more productive and my social anxiety is all but gone...." Read more

5 customers mention0 positive5 negative

Customers are dissatisfied with the seal of the vitamin. They mention that it's loose, broken, or stuck in the lid. Some say that the inner protective seal was not attached, and the tamper seal is crooked.

"...outer plastic, but once I twisted the lid open, the inner protective seal was not attached...." Read more

"Bottle had a broken seal and half the pills were missing." Read more

"Product came already opened. The seal had been removed under the cap. DANGER" Read more

"...had a wrinkled label covered by several other labels and the tamper seal is crooked - i have been using Thorne products and they have never been in..." Read more

This product is a lifesaver
5 Stars
This product is a lifesaver
THE Mthfr genetic mutation, can cause serious health issues, I have the mutation, and I had a simple blood test to confirm it. What this product does is absolutely amazing! It helps your body to methylate properly so you can absorb certain nutrients probably! And as always I trust THORNE PRODUCTS WITH MY LIFE. They are high quality and third party tested for heavy metals. If you or a loved one has had this test and has come back with the genetic MTHFR gene RUN DONT WALK TO BUY THIS PRODUCT! I have it on auto delivery every two months! You will not regret it!
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Top reviews from the United States

Reviewed in the United States on February 26, 2024
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5.0 out of 5 stars This product is a lifesaver
Reviewed in the United States on February 26, 2024
THE Mthfr genetic mutation, can cause serious health issues, I have the mutation, and I had a simple blood test to confirm it. What this product does is absolutely amazing! It helps your body to methylate properly so you can absorb certain nutrients probably! And as always I trust THORNE PRODUCTS WITH MY LIFE. They are high quality and third party tested for heavy metals. If you or a loved one has had this test and has come back with the genetic MTHFR gene RUN DONT WALK TO BUY THIS PRODUCT! I have it on auto delivery every two months! You will not regret it!
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8 people found this helpful
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Reviewed in the United States on March 7, 2024
One person found this helpful
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Reviewed in the United States on November 1, 2019
276 people found this helpful
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Reviewed in the United States on February 10, 2024
Reviewed in the United States on December 22, 2023
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4.0 out of 5 stars The Supplement Recommended on Rogans Podcast
Reviewed in the United States on December 22, 2023
I listen to a Joe Rogan podcast the other day with a guy on their name Gary Brecka. He gave a detailed breakdown on why many people are not getting enough B vitamins in their diet or the correct bio available form. This is the B vitamin from Thorne he recommended. Thorne is a solid company with great ingredients.

I did notice a slight uptick in my energy levels. When I take it with this energy supplement from Fasted Athlete I can really feel the effects. I don’t get tired in the afternoon anymore. I feel more alert, but not jittery. This is definitely a supplement that’s worth trying.
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37 people found this helpful
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Reviewed in the United States on January 28, 2024
15 people found this helpful
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Reviewed in the United States on March 19, 2024
Reviewed in the United States on March 15, 2024

Top reviews from other countries

romanchsharma
5.0 out of 5 stars Yes it’s the best thing
Reviewed in India on October 7, 2021
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romanchsharma
5.0 out of 5 stars Yes it’s the best thing
Reviewed in India on October 7, 2021
This is the best product for me. But its bit costly . It worth it
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satvir
5.0 out of 5 stars Five Stars
Reviewed in India on May 21, 2015

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