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Doctor's Best Stabilized R-Lipoic Acid with BioEnhanced Na-RALA, Helps Support Glucose Metabolism and Energy Production* Non-GMO, Gluten Free, Vegan, 100 mg, 180 Count
Purchase options and add-ons
Brand | Doctor's BEST |
Flavor | Unflavored |
Primary Supplement Type | Vitamin C |
Unit Count | 180 Count |
Item Form | Capsule |
Item Weight | 1.92 ounces |
Item Dimensions LxWxH | 2.25 x 2.25 x 4.35 inches |
Special Ingredients | Lipoic Acid |
Diet Type | Gluten Free |
Product Benefits | Antioxidant,Detox |
About this item
- DOCTOR’S BEST STABILIZED R-LIPOIC ACID CONTAINS BIOENHANCED NA-RALA - the sodium salt of R-Lipoic acid (RLA). BioEnhanced Na-RALA is in its natural and stabilized form of RLA that won’t degrade at high temperatures and is more bioavailable and biologically active. Lipoic acid (LA) plays an important role in glucose metabolism and energy production. LA is both fat and water soluble. D-Biotin is an integral part of enzyme activity necessary for the breakdown and conversion of fatty acids and carbohydrates into energy
- POWERFUL ANTIOXIDANT – Lipoic acid is a potent antioxidant that supports mitochondrial function, helps protect against oxidative stress and maintains cellular energy. Supports nerve health, glucose metabolism and cardiovascular health.
- CELLULAR ENERGY - R-lipoic acid is made by the body in our mitochondria, the cells that provide energy. Protecting mitochondria from free radicals, R-Lipoic Acid supports energy at the cellular level.
- BETTER ABSORPTION - R-Lipoic Acids includes the active “R” form of lipoic acid, stable and easier for the body to absorb. Improved stability from this formula is the cause for better absorption and bioavailability.
- During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
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Products with trusted sustainability certification(s). Learn more
Product Certification (1)
Compact by Design is a new sustainability certification created by Amazon to identify products that, while they may not always look very different, have a more efficient design. With the removal of excess air and water, products require less packaging and become more efficient to ship. At scale, these small differences in product size and weight lead to significant carbon emission reductions.
From the manufacturer
*These statements have not been evaluated by the Food and Drug Administration. This product in not intended to diagnose, treat, cure or prevent any disease.
**Stabilized R-Lipoic Acid contains BioEnhanced Registered.
Stabilized R-Lipoic Acid contains BioEnhanced** Na-RALA, the sodium salt of R-Lipoic acid (RLA). BioEnhanced** Na-RALA is in its natural and stabilized form of RLA that won’t degrade at high temperatures, and is more bioavailable and biologically active.*
Lipoic acid (LA) plays an important role in glucose metabolism and energy production. LA is both fat and water soluble. Studies suggests that LA may support the body’s antioxidant defenses.* D-Biotin is an integral part of enzyme activity necessary for the breakdown and conversion of fatty acids and carbohydrates into energy.
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What are the benefits of Stabilized R-Lipoic Acid?
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Why take Stabilized R-Lipoic Acid?
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How does it work?
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Alpha-lipoic acid is a sulfur-containing fatty acid that performs vitamin-like roles in the body. Also known as lipoic acid (LA) or thioctic acid, it functions as a co-enzyme in the metabolism of carbohydrates, and is in this way similar to B-complex vitamins. LA is required for synthesis of acetyl CoA, a key metabolite in the cellular process that turns glucose into energy. Because the body produces LA on its own, it is not classified as a true vitamin. As with other so-called "non-essential" nutrients, however, internal LA production may not always be optimal.
Alpha-lipoic acid functions as both a water-soluble and fat-soluble antioxidant. Free radicals are normal by-products of metabolism that, while necessary at normal levels, may damage tissues over time if not properly kept in check by antioxidants. Lipoic acid’s ability to neutralize free radicals in both watery and fatty environments makes it a highly versatile antioxidant. In the body, alpha-lipoic acid can be converted (reduced) to DHLA, or dihydrolipoic acid, a potent mitochondrial antioxidant. It is not necessary to take DHLA as a supplement, as the body may readily convert LA to DHLA.
What is BioEnhanced Na-RLA Stabilized R-Lipoic Acid? - Alpha-lipoic acid comes in two forms, designated as “R-lipoic acid” and “S-lipoic acid.” R- and S- lipoic acid are enantiomer isomers––molecules that appear as mirror images of each other. R-lipoic acid is naturally synthesized by humans, animals, and plants. S-lipoic acid is formed during chemical synthesis of alpha-lipoic acid, producing a “racemic” mixture of the two enantiomers that is often used in clinical studies on alpha-lipoic acid. Pharmacokinetic studies have shown that R-lipoic acid is more bioavailable than the S- form. For example, following single oral doses of 50 to 600 mg of racemic LA, maximum serum levels of the R- form were 40 to 50% higher than the S- lipoic form.
Best Stabilized R-Lipoic Acid contains BioEnhanced Na-RLA, the sodium salt of R-Lipoic acid (RLA). Pure RLA is a very unstable molecule that has a tendency to polymerize with exposure to heat, light, and moisture. This presents problems for those wishing to supplement with RLA, since any of these conditions can lead to deactivation of the beneficial activity of alpha-lipoic acid. Unlike pure RLA, BioEnhanced Na-RLA is a stabilized form of RLA that won’t degrade at high temperatures. By taking the sodium salt of RLA, its solubility is increased and it has an improved dissolution in the body. It is more bioavailable than regular RLA and has no solvent residues.
Note regarding sodium: The RLA in this product is stabilized with Na (sodium). However, one serving of this product contains less than 1% of the Daily Value for sodium, an insignificant contribution to dietary sources. Research suggests that sodium may impact blood pressure in some individuals only when it is consumed as sodium chloride (NaCl, table salt) and not in other forms. The sodium in this product is unlikely to affect blood pressure levels.
D-Biotin - Best Stabilized R-Lipoic Acid includes optically pure D-Biotin, the natural form of biotin. D-Biotin is a water-soluble vitamin and member of the vitamin B-complex that aids in the utilization of other B-complex vitamins. Integral to many of the activities of enzymes in the human body, D-biotin is necessary for the breakdown and conversion of fatty acids and carbohydrates into energy, allowing for the production of fats and excretion of protein breakdown products. Long-term administration of lipoic acid can lower the activities of the biotin-dependent enzymes pyruvate carboxylase and beta-methylcrotonyl-CoA carboxylase by competing with biotin. Supplementing with LA may thus increase the body's requirements for this vitamin.
Supports the body’s defense against free radicals*
Recycles antioxidant nutrients such as Vitamin C and Vitamin E*
An ideal antioxidant would have the ability to quench a wide variety of free radicals, to support the functioning of other antioxidants, to function in watery and fatty environments, and to be present in tissues, cells, and extracellular spaces. Having exceeded these criteria, Lipoic Acid was termed the “universal antioxidant.”
As a team, LA and DHLA come close to the ideal, for the following reasons:
1) LA is easily absorbed when consumed orally.
2) LA is readily converted to DHLA in various tissues.
3) As a pair, LA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals.
4) LA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions.
5) LA and DHLA scavenge free radicals in both fatty and watery environments.
6) DHLA recycles other important antioxidants.
Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which means it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E, and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduced forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants.
Helps maintain healthy glucose metabolism* - Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose for energy production. Researchers have noted that for a non-hormonal compound, LA is remarkable for its effect on carbohydrate metabolism—especially the R-lipoic form of alpha-lipoic acid. For example, in vitro studies have shown the ability of RLA to promote rapid uptake of glucose in muscle and fat cells.
The impact of lipoic acid administration in promoting healthy glucose metabolism is also evidenced in numerous animal and human studies. In one rat study, the known benefit of exercise on glucose uptake was complimented by 30 mg of RLA per kg body weight for 2 weeks. Glucose uptake into muscle increased by 45% in sedentary rats given RLA (compared to rats not receiving RLA); when the rats combined treadmill exercise with the RLA administration, glucose uptake jumped to 124% (compared to only 68% in rats given exercise but no RLA).16 After helping to initially increase glucose uptake into cells, RLA subsequently increases glucose utilization via activation of an enzyme complex—called the pyruvate dehydrogenase complex—involved in energy production inside the mitochondria of cells. LA is cited especially for its ability to reduce oxidative stress in the context of the important relationship between healthy glucose levels and vascular health.
Supports healthy aging* - As we age, our ability to synthesize lipoic acid decreases. Age also brings an accumulation of oxidized proteins that interfere with mitochondrial efficiency. LA’s status as a so-called “mitochondrial nutrient” addresses this situation. Furthermore, aging is accompanied by a decreased ability of the liver to recycle ascorbic acid following oxidative stress. R-lipoic acid, after two weeks of supplementation to aged rats, reversed the age-related impairment of ascorbic acid recycling and concentration in liver cells. A second study confirmed these results. Researchers determined that an RLA-supplemented diet fed to old rats for two weeks resulted in improved mitochondrial function, decreased free radical damage, and increased metabolic rate. Whereas a significant decline was seen in ascorbic acid and glutathione levels in the livers of the control rats, the RLA-supplemented group showed no decline in the levels of these critical antioxidants.
Supports cognitive function and brain health* - Aging is associated with oxidative stress in the brain. The brain's high rate of metabolism and its long-lived neurons make it particularly vulnerable to oxidative stress. Since LA interrupts cellular oxidative processes in both its oxidized and reduced forms, it plays a modulatory role in the brain and nervous system. One group of researchers found that LA decreased oxidative stress in the brain mitochondria of aged rats. This kind of activity inside of neurons may help explain the observed effect of LA administration on cognitive upkeep in an animal model. Evidence of cognitive benefits has cropped up in multiple studies on normal old mice, including one where longer-term memory was enhanced by LA. There are probably several mechanisms—in tandem with decreased oxidative stress—behind the cognitive support seen in these animal studies, including stimulated production of acetylcholine and enhancement of memory-related signaling pathways. Preliminary research on humans suggests that LA supports sustained cognitive function in older age.
Supports eye health* - Studies also indicate that supplementation with alpha-lipoic acid supports eye health. One of the most toxic chemicals in cigarette smoke, acrolein, is especially harmful to retinal pigment epithelial cells. Rats chronically exposed to low doses of acrolein lose the viability of these cells, showing a decrease in mitochondrial function due to oxidative stress. Pretreatment of these retina cells with LA before the acrolein exposure significantly protected them from oxidative damage. RLA is exceptionally suitable for supporting the retina of the eye. This was shown in rats, presumably via prevention of the activation of nuclear factor kappa B, a protein complex found in all cells that is involved in cellular responses to stimuli such as stress, free radicals, and ultraviolet irradiation. Studies in rats also demonstrate LA’s ability to support healthy retinal capillaries.
Supports cardiovascular health*
Alpha-lipoic acid may offer several different mechanisms in helping us to maintain cardiovascular health. From animal studies, researchers began to discover the impact of LA on blood lipids over half a century ago.28 Additionally, a recent study in mice demonstrated results seen in previous studies using mice or rats: lipoic acid lowered body weight gain and fat mass. Researchers attributed this to appetite suppression and enhanced energy expenditure. Mice in this same study also benefited from lower levels of triglycerides upon LA administration. While the favorable results seen in many of these in vivo studies have not yet been investigated in humans, researchers believe that LA supplementation holds promise for supporting the cardiovascular system through such means as helping to maintain a healthy weight and by promoting healthy lipid metabolism.
Stabilized R-Lipoic Acid vs. Controlled Release Products - Some companies are marketing controlled release or sustained release alpha-lipoic acid products, which maintain plasma concentrations for a longer period of time. However, available research adequately demonstrating the superiority of such products is lacking. Marketers of controlled release products claim that the therapeutic effectiveness of other lipoic acid products is limited due to the fact that it reaches peak concentrations in the bloodstream very quickly and therapeutic concentrations are not maintained. However, this is a misrepresentation of the large body of research indicating this is a fundamental beneficial property of lipoic acid, not a shortcoming.
Focus on sustainability
Small changes in product size & weight lead to lower carbon emissions.
We created Compact by Design to identify products that, while they may not always look very different, have a more efficient design. With the removal of excess air and water, products require less packaging and become more efficient to ship. At scale, these small differences in product size and weight lead to significant carbon emission reductions.
Here are a few of the many ways products can qualify:
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Product Description
Supports the body’s defense against free radicals. Recycles antioxidant nutrients such as Vitamin C and Vitamin E. An ideal antioxidant would have the ability to quench a wide variety of free radicals, to support the functioning of other antioxidants, to bind or “chelate” metal ions that can generate free radicals, to function in watery and fatty environments, and to be present in tissues, cells, and extracellular spaces. Having exceeded these criteria, Lipoic Acid was termed the “universal antioxidant.” As a team, LA and DHLA come close to the ideal, for the following reasons: 1) LA is easily absorbed when consumed orally. 2) LA is readily converted to DHLA in various tissues. 3) As a pair, LA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals. 4) LA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions. 5) LA and DHLA scavenge free radicals in both fatty and watery environments. 6) DHLA recycles other important antioxidants.
Product details
- Is Discontinued By Manufacturer : No
- Product Dimensions : 2.25 x 2.25 x 4.35 inches; 1.92 ounces
- Item model number : DRB-00229
- Date First Available : March 25, 2010
- Manufacturer : Doctor’s Best, Inc
- ASIN : B003E1OUKS
- Country of Origin : USA
- Best Sellers Rank: #9,507 in Health & Household (See Top 100 in Health & Household)
- #14 in Alpha Lipoic Acid Nutritional Supplements
- #1,488 in Sales & Deals
- #2,366 in Diet & Sports Nutrition
- Customer Reviews:
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This Item Doctor's Best Stabilized R-Lipoic Acid with BioEnhanced Na-RALA, Helps Support Glucose Metabolism and Energy Production* Non-GMO, Gluten Free, Vegan, 100 mg, 180 Count | Recommendations | dummy | dummy | dummy | dummy | |
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Price | -46% $46.09$46.09 List: $85.99 | $25.44$25.44 | $11.20$11.20 | -8% $36.99$36.99 List: $39.99 | -12% $11.75$11.75 Typical: $13.34 | $25.97$25.97 |
Price Per Unit | $0.26 / Count | $0.21 / Count | $0.09 / Count | $0.62 / Count | $0.39 / Count | $0.13 / Count |
Delivery | Get it as soon as Wednesday, Mar 13 | Get it as soon as Wednesday, Mar 13 | Get it as soon as Wednesday, Mar 13 | Get it as soon as Wednesday, Mar 13 | Get it as soon as Wednesday, Mar 13 | Get it as soon as Wednesday, Mar 13 |
Customer Ratings | ||||||
Easy to swallow | 4.4 | 4.6 | 4.1 | 4.6 | — | 4.7 |
Value for money | 4.0 | 4.3 | 4.3 | 4.4 | — | 4.7 |
Absorbency | 4.3 | 4.5 | 4.4 | — | — | 4.8 |
Flavor | — | 4.4 | 3.6 | 4.4 | — | 4.6 |
Sold By | Amazon.com | Amazon.com | Amazon.com | Nature's Fusions Nutri | Health Chest | Superior Labs |
keyword type | alpha-lipoic-acid-nutritional-supplements | alpha-lipoic-acid-nutritional-supplements | alpha-lipoic-acid-nutritional-supplements | alpha-lipoic-acid-nutritional-supplements | alpha-lipoic-acid-nutritional-supplements | acetyl-l-carnitine-nutritional-supplements |
form | Capsule | Tablet | Capsule | Capsule | Tablet | Capsule |
flavor | Unflavored | Unflavored | blood sugar | — | Unflavored | Unflavored |
size | 180VC | 120 Servings (Pack of 1) | 120 Count (Pack of 1) | 60 Count (Pack of 1) | 30 Tablets | 200 Count (Pack of 1) |
weight | 0.12 pounds | 5.93 ounces | 0.15 pounds | 0.12 pounds | 0.07 pounds | — |
age range | Adult | Adult | Adult | Adult | Adult | Adult |
product benefit | Antioxidant,Detox | Energy Management | Antioxidant | Antioxidant, Cellular Energy, Mitochondrial Function | Antioxidant | Heart Health Support |
Important information
Safety Information
not availableThis product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings
Indications
not available
Ingredients
D-Biotin 150 mcg, R-Lipoic acid (from Sodium R-alpha Lipoate (BioEnhanced Na-RALA)) 100 mg, Modified cellulose (vegetarian capsule), rice powder, microcrystalline cellulose, magnesium stearate (vegetable source), silicon dioxide.
Directions
One to two capsules daily, or as directed by a health care professional. Store in a cool dry place.
Legal Disclaimer
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
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Customer reviews
Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them.
To calculate the overall star rating and percentage breakdown by star, we don’t use a simple average. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. It also analyzed reviews to verify trustworthiness.
Learn more how customers reviews work on AmazonCustomers say
Customers like the performance, effect on stomach pain, value, hunger and ease of use of the nutritional supplement. They mention that it works great, provides noticeable relief and is good value for money. Customers are also happy with energy, side effects, and antioxidant.
AI-generated from the text of customer reviews
Customers like the performance of the nutritional supplement. They say it works great, is easy to swallow, and has no issue. Some say that it helped with egg quality and gave quick results.
"...and have taken but one cap a few hours ago I am confident it will prove quite effective...." Read more
"...reaction-time has improved since taking these - however, i DO take "ala" also, for my leg pain, and these two seem to compliment each other." Read more
"Easy to take, great product 👍🇺🇸..." Read more
"...'ve done on Alpha Lipoic Acid indicates R-Lipoic Acid is the most effective form of ALA." Read more
Customers like the effect on stomach pain. They mention that it provides noticeable relief, helps chronic nerve pain, and keeps foot discomfort in check. Some customers also say that it doesn't irritate their stomach. Overall, customers are satisfied with the product's effectiveness in treating nerve pain and stopping or reversing peripheral neuropathy, which is common with diabetics.
"...It worked well for that as my feet are now almost pain free....BUT some added benefits I was not counting on...." Read more
"...I received no additional pain relief, in fact I think it's increased a bit.So if it works for you, great!..." Read more
"...I have experienced no negative side effects, especially no upset stomach when I take it early in the morning before breakfast or yoga class...." Read more
"...that the burning feeling was completely gone, and the numbness and tingling was reduced by at least 50%...." Read more
Customers like the value of the nutritional supplement. They mention that it has a good price for the product, the capsules are easy to swallow, and it is the best for its size and cost. Some appreciate that it contains biotin, which they were taking.
"...this is by far the best one that I have ever encountered and at a very good price especially if you subscribe...." Read more
"...I figured hey, this stuff is more bioavailable so it must be better! Well, in my case this wasn't so...." Read more
"...The price is similar so I will be placing my order for this item there instead." Read more
"My experience with this stabilized R-ALA is that it's much more expensive than regular ALA and has performed less than regular ALA I was taking." Read more
Customers are satisfied with the hunger-reducing effect of the product. They mention that it helps to keep their blood sugar in check, is good for diabetes, and helps to burn off the sugar. Some customers also mention that the product suppresses their appetite and increases insulin sensitivity. Overall, customers are happy with the product's ability to increase insulin senitivity and reduce hunger.
"...I have been taking this for 4 months now.1. Blood glucose control...." Read more
"...And it helps lower blood sugar. The Na is suppose to be more stable...." Read more
"...love this stuff. Lowers blood sugar, too." Read more
"...But this pill was lowering my blood sugar anywhere from 10 to 25 points! I take it three times a day roughly with each meal...." Read more
Customers find the nutritional supplement easy to use. They mention it's easy to swallow, easy on the stomach, and is a great product for its size and cost.
"Easy to take, great product 👍🇺🇸..." Read more
"...This brand is much easier to swallow." Read more
"...I can't tell the difference except that this is much easier to swallow." Read more
"...I am very pleased and it's so easy to take and I like the fact that it's taken once a day only. There is no downside as far as I can tell...." Read more
Customers like the energy of the nutritional supplement. They say it gives them more energy, they never get the mid-day energy slump, and they've noticed a positive difference in their mood and cognition. Some say that the product helps with kick-starting their day and their new workout regimen. They also say it's easy on the stomach and helps with normal sleep patterns.
"...Granted, it does give me a lot of energy if I add more carbs to my meal, which I make sure that I do when I plan to ingest R-lipoic acid from this..." Read more
"...is a bit too early to see all the benefits but I already am started a bit more energetic and know my heart will like it...." Read more
"...Easy on the stomach, normal sleep patterns, very easy to swallow, everything checks out okay...." Read more
"...Regular intake of Dr.'s Best R-Lipoic gives a nice energy boost and clears out the mental cobwebs...." Read more
Customers like the side effects of the product. For example, they mention that it's important for their health and has no negative side effects. Some say that the product is an antioxidant and has a host of other useful health effects.
"...Don't really know what it's supposed to do, but no side effects" Read more
"...I have experienced no negative side effects, especially no upset stomach when I take it early in the morning before breakfast or yoga class...." Read more
"...There is no downside as far as I can tell. I will be ordering again soon. Thanks." Read more
"...I think because they also regulate/lower blood sugar, they had a negative effect. I don't have issues with that...." Read more
Customers like the antioxidant. They say it is very good as an antioxidant, and a great anti-oxidant for protecting mitochondrial function. It definitely improves detoxification, and helps with weight loss. Customers also say it clears out the mental cobwebs.
"...since 12/2013 and its antioxident effects definitely have helped me stay and feel healthy even though everyone else was getting sick and it also was..." Read more
"...It is an especially important antioxidant for Mitochondria. And it helps lower blood sugar. The Na is suppose to be more stable...." Read more
"This is a very good detoxifier, among other things. It definitely does work to chelate the heavy metals as well as other toxins out of the body...." Read more
"...Anyway, R-Lipoic is a really good anti-oxidant -- I find that in combination with multi-vitamins, that I feel and operate great!..." Read more
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Top reviews from the United States
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Yesterday I put PR's 1+ remaining bottles in a drawer in frustration and ordered this Doctor's Best stabilized Na-RALA. With one-day Amazon Prime shipping it arrived today. I then emptied a 100mg cap each of the PR R-ALA and Doctor's Best Na-RALA onto a paper plate, and set the plate (covered with another paper plate turned upside down to heat quicker) on top of a hot radiator for an hour. Stabilized Na-RALA is resistant to heat (above 90 degrees F) and absorbs much easier (with concomitant enhanced bio-availability) than non-stabilized R-ALA (which breaks down into rubbery lumps when exposed to heat above 90 degrees F and loses any health benefit in the process). See the attached photo for the results. The yellowish, rubbery lumps at the top of the plate are from the PR brand, which I was assured by a PR customer rep was stabilized. The white, still powdery and unaffected substance at the bottom of the plate is Doctor's Best Stabilized Na-RALA. The results of this easy experiment speak for themselves. I would also add that I had to pry the PR brand R-ALA out of its capsule with a toothpick, that it was already partly solidified (not good) and lumping up inside, and sticking to the inside of the cap, and that the Doctor's Best Na-RALA spilled right out as a powder.
If you cannot be certain the R-ALA you are thinking of buying is Stabilized, use your own best judgment, but I would advise against buying it. Think of unstabilized R-ALA riding around in the back of an un-airconditioned delivery truck for hours or maybe a full day in the heat of summer and hope your product can stand the heat. I have actually received a few packages of various supplements this way and believe me, the plastic packages were _hot_ to the touch, as were the plastic bottles inside. Why take a chance?
While I have just received my first bottle of Doctor's Best stabilized Na-RALA and have taken but one cap a few hours ago I am confident it will prove quite effective. I will update this review in the near future when I have more data points to work from with what appears to be an excellent product.
Reviewed in the United States on January 20, 2018
Yesterday I put PR's 1+ remaining bottles in a drawer in frustration and ordered this Doctor's Best stabilized Na-RALA. With one-day Amazon Prime shipping it arrived today. I then emptied a 100mg cap each of the PR R-ALA and Doctor's Best Na-RALA onto a paper plate, and set the plate (covered with another paper plate turned upside down to heat quicker) on top of a hot radiator for an hour. Stabilized Na-RALA is resistant to heat (above 90 degrees F) and absorbs much easier (with concomitant enhanced bio-availability) than non-stabilized R-ALA (which breaks down into rubbery lumps when exposed to heat above 90 degrees F and loses any health benefit in the process). See the attached photo for the results. The yellowish, rubbery lumps at the top of the plate are from the PR brand, which I was assured by a PR customer rep was stabilized. The white, still powdery and unaffected substance at the bottom of the plate is Doctor's Best Stabilized Na-RALA. The results of this easy experiment speak for themselves. I would also add that I had to pry the PR brand R-ALA out of its capsule with a toothpick, that it was already partly solidified (not good) and lumping up inside, and sticking to the inside of the cap, and that the Doctor's Best Na-RALA spilled right out as a powder.
If you cannot be certain the R-ALA you are thinking of buying is Stabilized, use your own best judgment, but I would advise against buying it. Think of unstabilized R-ALA riding around in the back of an un-airconditioned delivery truck for hours or maybe a full day in the heat of summer and hope your product can stand the heat. I have actually received a few packages of various supplements this way and believe me, the plastic packages were _hot_ to the touch, as were the plastic bottles inside. Why take a chance?
While I have just received my first bottle of Doctor's Best stabilized Na-RALA and have taken but one cap a few hours ago I am confident it will prove quite effective. I will update this review in the near future when I have more data points to work from with what appears to be an excellent product.
1. Blood glucose control. Daily fasting glucose dropped at least 10-15 mg/dcl and am now running around 90 daily as opposed to 110-115.
2. My skin! I did not expect this! I didn't even think about this when I purchased this because I was focusing on the misery of my feet....but suddenly noted after probably 2 months of taking it that the RED sun damage on my arms, neck and legs is GONE!. And my brown ones have greatly faded! My skin easily looks 10 years younger. No effect on wrinkling, just coloration.
If I can afford it, I will probably take this for life. I am an RN and usually skeptical about herbal or vitamin products, and will also throw in that when I temporarily ran out of this I bought some regular ( non-R) at CVS that did not work at all. I will update this review in 6 months or so
1. my reflexes are much better when i take these (i'm OLD)
2. i like the fact that they're 'probably' helping strengthen my immune system.
reaction-time has improved since taking these - however, i DO take "ala" also, for my leg pain, and these two seem to compliment each other.
ALA is an interesting vitamin in that it comes in a variety of types even though most don't actually label which type you are getting. When traditional ALA is made synthetically it is a 50/50 blend of two different types of ALA ( R and S types). These types are mirror images of each other molecularly but, studies have shown that only the R type is actually used by the body though so most ALA supplements are actually only 50% effective and the S type is just turned into expensive pee.
Some companies will filter out the R type which is better but even then most of the ALA that you take cannot be absorbed by the body. This is why this brand uses Sodium (Chemical symbol Na) to bond to the ALA which then lets the body absorb 250% more and let it actually get into the blood stream. So this product is actually chemically 5 times as effective as a R & S blend and 2.5 times more effective than an R-ALA vitamin. Search on PubMed or other medical journal sites and you'll find mountains of actual clinical evidence touting NA-R-ALA for many different reasons.
I've been taking it very regularly since 12/2013 and its antioxident effects definitely have helped me stay and feel healthy even though everyone else was getting sick and it also was a clear trigger in helping me lose weight by stabilizing blood sugar levels.
At first it did give me pretty bad stomach aches until I got use to it and now I can easily take it with no discomfort even without food.
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