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Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply

4.5 4.5 out of 5 stars 69,188 ratings

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6-Pack
Large Cat only

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About this item

  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application

Customer ratings by feature

Easy to use
4.3 4.3
Scent
3.8 3.8
Value for money
3.7 3.7

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Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply
Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply
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Price-10% $68.98
List:$76.78
$55.96$34.98$39.98-10% $51.98
List:$57.58
-10% $32.48
List:$35.98
Delivery
Get it as soon as Monday, Mar 18
Get it as soon as Monday, Mar 18
Get it as soon as Monday, Mar 18
Get it as soon as Monday, Mar 18
Get it as soon as Monday, Mar 18
Customer Ratings
Easy to use
4.3
4.6
3.9
2.9
4.3
4.2
Scent
3.8
3.4
3.6
2.2
3.8
3.7
Value for money
3.7
3.5
3.4
1.9
3.7
3.5
Sold By
Amazon.com
Pets Go Here - Pet Store
Amazon.com
PETIQ
Amazon.com
Amazon.com
target audience
Adult
Adult
Cat, Cat, Cat, Cat, Cat
Cat, Cat, Cat, Cat, Cat
Adult
age range
8 weeks and older
Kitten
8 weeks and older
All Life Stages
8 weeks and older
8 weeks and older
scent
Unscented
Unscented
Unscented
Unscented
Unscented
form
Topical
Drops
Topical
Drops
Topical
Topical
volume
4.8 milliliters
2 fluid ounces
1 milliliters
3.2 milliliters
0.8 milliliters
active ingredients
Imidacloprid, Pyriproxyfen
Spinetoram
Fipronil, Cyphenothrin, (S)-methoprene
Imidacloprid, Pyriproxyfen
Imidacloprid, Pyriproxyfen
weight
0.05 pounds
0.05 pounds
0.05 pounds
0.05 pounds
0.04 pounds

From the manufacturer

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Cat lovers choose Advantage II Large Cat

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Kills and Protects

Kills adult fleas, flea larvae and flea eggs to break the flea life cycle and prevent further infestations.

Same-Day Effectiveness

Kills fleas on cats within 12 hours of application and continues to prevent infestations for a month.

Vet-Recommended

A leading brand in cat flea treatment and prevention, recommended for large cats over 9 lbs.

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About Advantage II

  • Easy-to-apply topical solution – no hard-to-swallow pills
  • 30-day protection
  • Fragrance-free, waterproof formula*

*24 hours after application

Easy Application - Step 1

Holding the tube upright and pointed away from you and your pet, remove the cap from the applicator tube. Turn the cap around, place it back on the tube and twist to break the seal.

Easy Application - Step 2

Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin.**Do not get this product in your cat’s eye or allow your cat to ingest this product.

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image image image image image
Advantage II Large Cat Advantage XD Large Cat Advantage II Kitten Seresto Cat Advantage Cat Spray
Customer Reviews
4.5 out of 5 stars
69,188
4.3 out of 5 stars
1,211
4.4 out of 5 stars
7,805
4.5 out of 5 stars
38,065
4.0 out of 5 stars
719
Form Topical Drops Topical Drops Topical Drops Collar On-Pet Spray
Treatment Treatment + Prevention Treatment + Prevention Treatment + Prevention Treatment + Prevention Treatment
Application Frequency Monthly Every 2 Months Monthly Every 8 Months See Product Label
Kills Fleas?
Kills Ticks?
Starts to Kill Fleas Within 12 hours 30 mins - 4 hrs 12 hours 24 hours On Contact

Looking for specific info?

Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 1.38 x 4.38 x 6.63 inches; 0.8 ounces
  • Item model number ‏ : ‎ 86336774
  • Date First Available ‏ : ‎ March 2, 2011
  • Manufacturer ‏ : ‎ Elanco US Inc
  • ASIN ‏ : ‎ B004QBDO0M
  • Country of Origin ‏ : ‎ Germany
  • Customer Reviews:
    4.5 4.5 out of 5 stars 69,188 ratings

Product Description

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.

Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.

That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.

Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.

For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment.

Advantage II Large Cat is a trademark of Elanco or its affiliates.

Top Brand: Advantage

Highly Rated
4.5/5 star rating from 100K+ customer ratings
Trending
100K+ orders for this brand in past 3 months
Low Returns
Customers usually keep items from this brand

Important information

Ingredients

Other

Directions

Application Instructions: 1. Use only on cats. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Part the hair at the base of the cat’s skull until skin is visible. 5. Evenly apply the entire contents of the Advantage II tube directly on the skin by squeezing the entirety of the contents in that one spot. Do not get this product in your cat’s eyes, or allow your cat to ingest this product.

Legal Disclaimer

Avoid contact with children to treated area until treatment is Dry.

To report an issue with this product or seller, click here.

Customer reviews

4.5 out of 5 stars
4.5 out of 5
69,188 global ratings

Customers say

Customers like the performance, effect on fleas, and delivery of the pet pest control product. They mention that it works well, keeps the flea problem under control, and is easy to use. Customers are also satisfied with the value, and ease of use. However, some customers disagree on comfort and quality.

AI-generated from the text of customer reviews

4,371 customers mention3,216 positive1,155 negative

Customers like the performance of the pet pest control product. They say it works well and keeps fleas away. Some say that it works right away and for a long time, and is excellent and effective. Overall, most are happy with the product's performance and recommend it to others.

"PROS: works well, appropriate for large cats, easy application, ability to buy in bulk..." Read more

"...However, it's absolutely worth it. It works very well and I've always felt that my cats not suffering is more important than the price tag...." Read more

"...The only problem I have is the smell. It is horrible and my cat doesn't like the smell neither...." Read more

"I use this monthly and appears to work. No side effects from my cat are noticeable. No fleas." Read more

2,253 customers mention1,670 positive583 negative

Customers like the effect on flea. They mention that it keeps the flea problem under control, and most of the flees are dead. It does a magnificent job of delivering total flea protection, and is reliable. It also reduces dust from the DE, and does e a great job of keeping their cats safe.

"...It also reduced dust from the DE...." Read more

"...No side effects from my cat are noticeable. No fleas." Read more

"...I compared and chose this. It worked! No fleas, BUT in November, I discovered a attached tick to our cat Sam...." Read more

"...is cheaper but in order for frontline to work, the fleas have to bite the animals. This product does not require them to be bitten...." Read more

1,586 customers mention1,115 positive471 negative

Customers like the value of the pet pest control. They mention it's a good price and absolutely worth it.

"Best price deal" Read more

"Better price than most places." Read more

"...CONS: expensive, sometimes applicator breaks, stinky smell!..." Read more

"...So...if you see some fleas on your pets, get some advantage, it's rather cheap (compared to paying for something at the vet or petsmart)...." Read more

568 customers mention534 positive34 negative

Customers find the pet pest control easy to use. They mention that it is appropriate for large cats, easy application, and can be bought in bulk. Some customers also mention that the product is easy to apply if their cats are resting.

"PROS: works well, appropriate for large cats, easy application, ability to buy in bulk..." Read more

"...It's even easy to use on our most skiddish cat. She barely notices we are doing it. My only complaint is I wish it would dry faster...." Read more

"It's not hard to apply by themselves however multiple cats need to be separated and nailed at the same time ish...." Read more

"...Keeps the fleas off and is easily applied." Read more

390 customers mention376 positive14 negative

Customers are satisfied with the delivery of the pet pest control product. They say that it works fast, comes quickly, and is easy to dispense. They also appreciate the easy access ordering from Amazon, and the fact that it gets delivered to their house monthly.

"...But here on Amazon you would definitely get it cheaper and pretty fast...." Read more

"Worked very fast." Read more

"...II for the larger cat (2 are at the borderline weight) and it WORKED INCREDIBLY FAST!!!!..." Read more

"Pretty good price and love that it gets delivered to my house monthly and I don't have to try and remember to pickup flea medicine for my cat...." Read more

320 customers mention271 positive49 negative

Customers generally like the effect on cat. They mention that their cat did not have any ill effects from it, had no allergic reactions or negative side effects, and it worked great to keep them flea free. They also mention that it works and works well by not harming the animals and by killing fleas. Some didn't like it, but it was safer and easier than flea baths, and is totally pet safe.

"...My cats didn't like it, but it was safer and easier than flea baths!..." Read more

"I use this monthly and appears to work. No side effects from my cat are noticeable. No fleas." Read more

"This worked well for my 19 pound kitty with no noticeable side effects" Read more

"...They did not have any reactions to the medication and it started working after about a day...." Read more

540 customers mention330 positive210 negative

Customers are mixed about the comfort of the product. Some mention that within 24 hours the itching and scratching was significantly diminished, while others say that it gave them a terrible skin reaction to the chemicals in just one dose. They all make their cats not feel very well, and this product really makes them sick.

"...For once in little over a year, my cats are FINALLY comfortable. And I am so happy I bought this...." Read more

"...Cats had a bad reaction to it. It’s made them sick and gave them muscle spasms. This is all I’ll ever use." Read more

"...At least they're not scratching as much, and the sores around their necks are actually starting to scab over which is so wonderful...." Read more

"...I applied the application and within a day I noticed my kitties weren't scratching and b/c of the fleas one of my cats got dermatitis & started..." Read more

428 customers mention255 positive173 negative

Customers are mixed about the quality of the pet pest control product. Some mention that it has consistently made their cats feel bad, while others say that it made both of their cats ill, which has never done before. Some say that the treatment was completely ineffective in reducing the numbers of fleas, and that it is not as good as Revolution for a spot treatment.

"PROS: works well, appropriate for large cats, easy application, ability to buy in bulk..." Read more

"They all make my cats not feel very well. But this one really makes my cats sick. Lasts 3 weeks in a coastal oregon summer" Read more

"...Pills or liquid are not cats favorite. Happy cats, no bleeding scratches. I shop around, but mainly wait fir these to go on sale. Great buy...." Read more

"...Defective dose maybe?" Read more

READ THIS
5 Stars
READ THIS
With my review i am going to address points from reviews posted. This review is only based on my personal experiences.1. Price. Yes, this product is expensive. However, it's absolutely worth it. It works very well and I've always felt that my cats not suffering is more important than the price tag. Also, here on amazon is significantly cheaper than other places. (Saved $20 buying it here instead of 1800petmeds)2. Balding. There are a few things that need to be known for this product. Make sure you are using the appropriate dose for your cats. Weigh them. Do not assume their weight. If they are on the borderline, use the smaller dose or dont use all of the larger one. Also dont put it all in one spot. Make a line from the back of their neck to their shoulder blades.3. "Frontline is cheaper and does the same thing". Incorrect! Frontline is cheaper but in order for frontline to work, the fleas have to bite the animals. This product does not require them to be bitten.4. "Fleas didnt go away." You cannot expect any flea product to completely rid your home of them. It takes a minimum of 3 months to completely get rid of them if you actively fight against the fleas. You need to vacuum your floors and furniture every day at least for awhile. You also need to keep up with your laundry and wash blankets regularly, including your bedding. And its also very important to be spraying your furniture down with flea spray. RAID or Hotshot work wonders for this! Spray your furniture and bedding down every night. I also spray in the crevices of my apartment because fleas like to hide.5. "Fleas were going everywhere so i had to give them a flea bath." Do NOT do this. Them jumping off your pets is a GOOD thing! That means the product is working. If you bathe them before the product has time to set it, you just wasted your money. This is why you need to be keeping up with prevention in your home. Theyre jumping off your animal because the product is working. Vacuuming, washing, and spraying is what will combat the infestation.You CANNOT get rid of fleas completely in a short period of time so dont expect a miracle. That's where people get disappointed. Let the product do its job and play catch up for the next few months. And make sure you're keeping up with the doses!!
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Top reviews from the United States

Reviewed in the United States on July 24, 2016
Size: 6-PackStyle: Large Cat onlyVerified Purchase
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5.0 out of 5 stars REVIEW OF ADVANTAGE II LARGE CAT FLEA CONTROL
Reviewed in the United States on July 24, 2016
PROS: works well, appropriate for large cats, easy application, ability to buy in bulk
CONS: expensive, sometimes applicator breaks, stinky smell!

I first purchased this product in August 2015, Again in Janurary 2016, and I just purchased this again (July 2016). I purchased this product to help control fleas on my two cats, one of which is an indoor/outdoor cat. The neighborhood I live in has terrible fleas, so using flea medication is essential.

The product arrived quickly, and came with thorough instructions, which I skimmed. The medication comes in a tiny tube incased in a foil packet. I opened the packet, and took out the tube. You break the seal on the tube by inverting the cap and puncturing the seal. I did this and accidentally twisted, causing the point on the top of the lid to become lodged in the opening of the tube. This was stressful because each treatment is so expensive. I realized, however, that I could fish out the point with some tweezers and still use the product! I then pinned my cat down and applied the product to the back of their neck. While I did see a decrease in fleas, I still saw several. I increased application to once every two weeks, and added baths and flea combing to the regime. Eventually, I was able to apply only once a month. During the summer the flea population seems to increase, which also coincided with my adoption of a second cat. I noticed the cat came in with fleas and I applied this medication, but it didn't seem to do much. I then woke up one morning with about 30 flea bites covering my lower legs and feet! I was horrified, and I knew it was time to get serious!

After a bit of research I realized apart of why the medication may have been ineffective previously was that I wasn't applying it correctly (ha! Thats what i get for skimming!) Rereading instructions, I realized that I need to part my cats fur and try to make skin contact with the medication. I also learned that if my cats lick it it will taste bitter, discouraging licking behaviors of the medication. I'm going to include a few steps I took to control fleas in my house, unrelated to this product, but I think it might be useful! Scroll down to my conclusion if uninterested :) Anyways, so my cats hate baths (they were both rescued and are older so its hard to introduce new behaviors, I mean, I'm no jackson galaxy) For this reason flea baths always stressed me out and I was worried about my cats catching a cold or licking the flea shampoo and getting sick.Instead of bathing my cats, I gave them a pill that will kill all the fleas on them within 6 hours( https://www.amazon.com/Novartis-Capstar-Flea-Tablets-Count/dp/B005Z6UL1M/ref=sr_1_2?ie=UTF8&qid=1469319334&sr=8-2&keywords=flea+killer+pill). Using this pill in conjunction with this treatment, was a life saver! The next thing I did was give my pets a dry, diatomaceous earth bath. If you choose to do this with your cats, make sure you use food grade DE. DE is a great natural alternative for flea control, but the dust can be damaging to yourself and your cats! To prevent this, I wore a bandana around my mouth, and I stuck a comfy cone on my cat ( https://www.amazon.com/Comfy-Cone-E-Collar-Large-Black/dp/B000XY7CKE/ref=sr_1_1?ie=UTF8&qid=1469319818&sr=8-1&keywords=comfy+cone). My cats didn't like it, but it was safer and easier than flea baths! I also put some apple cider vinegar diluted with water in a spray bottle, and I sprayed down my cats. They hated this, but I think it maybe helped the fleas? It also reduced dust from the DE.

CONCLUSION: I think that all cat owners should use this product on their cats, even if their cats are indoor cats. an inch of prevention is worth a pound of solution, and this is especially true for fleas. Make sure to treat your cats regularly and make sure you apply it correctly!

included some photos of my happy flea free cats :)
Images in this review
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Customer imageCustomer imageCustomer imageCustomer image
31 people found this helpful
Report
Reviewed in the United States on June 20, 2017
Size: 6-PackStyle: Large Cat onlyVerified Purchase
Customer image
5.0 out of 5 stars READ THIS
Reviewed in the United States on June 20, 2017
With my review i am going to address points from reviews posted. This review is only based on my personal experiences.
1. Price. Yes, this product is expensive. However, it's absolutely worth it. It works very well and I've always felt that my cats not suffering is more important than the price tag. Also, here on amazon is significantly cheaper than other places. (Saved $20 buying it here instead of 1800petmeds)
2. Balding. There are a few things that need to be known for this product. Make sure you are using the appropriate dose for your cats. Weigh them. Do not assume their weight. If they are on the borderline, use the smaller dose or dont use all of the larger one. Also dont put it all in one spot. Make a line from the back of their neck to their shoulder blades.
3. "Frontline is cheaper and does the same thing". Incorrect! Frontline is cheaper but in order for frontline to work, the fleas have to bite the animals. This product does not require them to be bitten.
4. "Fleas didnt go away." You cannot expect any flea product to completely rid your home of them. It takes a minimum of 3 months to completely get rid of them if you actively fight against the fleas. You need to vacuum your floors and furniture every day at least for awhile. You also need to keep up with your laundry and wash blankets regularly, including your bedding. And its also very important to be spraying your furniture down with flea spray. RAID or Hotshot work wonders for this! Spray your furniture and bedding down every night. I also spray in the crevices of my apartment because fleas like to hide.
5. "Fleas were going everywhere so i had to give them a flea bath." Do NOT do this. Them jumping off your pets is a GOOD thing! That means the product is working. If you bathe them before the product has time to set it, you just wasted your money. This is why you need to be keeping up with prevention in your home. Theyre jumping off your animal because the product is working. Vacuuming, washing, and spraying is what will combat the infestation.

You CANNOT get rid of fleas completely in a short period of time so dont expect a miracle. That's where people get disappointed. Let the product do its job and play catch up for the next few months. And make sure you're keeping up with the doses!!
Images in this review
Customer image Customer image Customer image
Customer imageCustomer imageCustomer image
2,208 people found this helpful
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Reviewed in the United States on March 3, 2024
Size: 6-PackStyle: Large Cat onlyVerified Purchase
Reviewed in the United States on December 11, 2023
Size: 2-PackStyle: Large Cat onlyVerified Purchase
One person found this helpful
Report
Reviewed in the United States on March 5, 2024
Size: 6-PackStyle: Large Cat onlyVerified Purchase